English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  The physicochemical properties of nanoparticles (NPs) influence their biological outcomes.    Methods  We assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO 2  NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated and silica-coated CeO 2  NPs were generated by flame spray pyrolysis and later neutron-activated. These radioactive NPs were IT-instilled, gavaged, or intravenously (IV) injected in rats. Animals were analyzed over 28 days post-IT, 7 days post-gavage and 2 days post-injection.    Results  Our data indicate that silica coating caused more but transient lung inflammation compared to uncoated CeO 2 . The transient inflammation of silica-coated CeO 2  was accompanied by its enhanced clearance. Then, from 7 to 28 days, clearance was similar although significantly more  141 Ce from silica-coated (35 %) was cleared than from uncoated (19 %)  141 CeO 2  in 28 days. The protein coronas of the two NPs were significantly different when they were incubated with alveolar lining fluid. Despite more rapid clearance from the lungs, the extrapulmonary  141 Ce from silica-coated  141 CeO 2  was still minimal (<1 %) although lower than from uncoated  141 CeO 2  NPs. Post-gavage, nearly 100 % of both NPs were excreted in the feces consistent with very low gut absorption. Both IV-injected  141 CeO 2  NP types were primarily retained in the liver and spleen. The silica coating significantly altered the plasma protein corona composition and enhanced retention of  141 Ce in other organs except the liver.    Conclusion  We conclude that silica coating of nanoceria alters the biodistribution of cerium likely due to modifications in protein corona formation after IT and IV administration.

Silica coating influences the corona and biokinetics of cerium oxide nanoparticles