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Background   Salvia hispanica  seeds have been commonly used by people that seek healthy habits through natural foods to reduce cholesterol and triacylglycerides levels, however, the evidences that support this assumption are still scarce in literature. Here, we aimed to evaluate the lipid lowering effects of chia by using  Caenorhabditis elegans  as animal model, a nematode that has proven its usefulness for lipid metabolism studies.    Methods  We prepared hexane (HE) and Bligh-Dyer (BDE) extracts, evaluated and compared their safety, antioxidant potential and their lipid-lowering activity in the worms.    Results  The characterization of both extracts demonstrated that there were no differences in their lipid composition; however, BDE depicted better antioxidant potential. Both extracts reduced worm’s survival from 2%, and reproduction was reduced following treatment with both extracts, though a more notable effect was observed in HE-treated worms. In addition, the non-toxic concentration of both extracts (1%) increased stress resistance against paraquat toxicity in an antidote paradigm. Notably, this same concentration of both extracts reduced lipid accumulation in obese worms, which was not caused by food deprivation.    Conclusions  Taken together, our data demonstrate that both extraction methods from chia seeds result in oils that are rich in mono and polyunsaturated fatty acids, which may modulate lipid accumulation and provide antioxidant resistance in  C. elegans.

Salvia hispanica L. (chia) seeds oil extracts reduce lipid accumulation and produce stress resistance in Caenorhabditis elegans