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Background  This study aimed to assess the association between the angiopoietin-like protein 4 gene ( ANGPTL4 ) single nucleotide polymorphisms (SNPs) and serum lipid levels, the risk of coronary artery disease (CAD) and ischemic stroke (IS), and response to atorvastatin therapy in a Southern Chinese Han population.    Methods  Genotypes of the  ANGPTL4  rs4076317, rs7255436, rs1044250 and rs2967605 SNPs in 1,654 unrelated subjects (CAD, 568; IS, 537; and controls, 549) were determined by the Snapshot technology. Another group of 724 hyperlipidemic patients was selected and treated with atorvastatin calcium tablet 20 mg/day for 8 weeks.    Results  The rs2967605 CT/TT genotypes were associated with a decreased risk of CAD (adjusted OR = 0.68, 95% CI = 0.47-0.99,  P  = 0.043 for CT/TT  vs . CC) and IS (adjusted OR = 0.55, 95% CI = 0.38-0.80,  P  = 0.020 for CT/TT  vs . CC). There was no significant association between the four SNPs and angiographic severity of CAD. The subjects with the rs4076317 CG/CC genotypes in controls had higher total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels than the subjects with the GG genotype ( P  < 0.001; a  P  < 0.0018 was regarded statistically significant by the Bonferroni correction). The subjects with rs4076317CG/GG genotypes had lower TC and LDL-C levels than the subjects with CC genotype after atorvastatin treatment ( P  < 0.001).    Conclusions  The observed associations suggest that the  ANGPTL4  variants have a potential role on serum lipid levels and atherosclerosis-related diseases in the Chinese Han population, especially the  ANGPTL4  rs4076317 and rs2967605 SNPs.

nutrition and metabolism

ANGPTL4 variants and their haplotypes are associated with serum lipid levels, the risk of coronary artery disease and ischemic stroke and atorvastatin cholesterol-lowering responses