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Elderly people have experienced several influenza natural infections and seasonal vaccinations during their lives. The aim of this work was to evaluate in an elderly Spanish population the presence of antibodies (Abs) against some 1940s era A/H1N1 influenza viruses and some new influenza viruses. We also evaluated the homologous and heterotypic responses after seasonal influenza vaccination. We collected pre- and post-vaccination serum samples from 174 elderly people (≥65 years) who were vaccinated with seasonal influenza vaccines during the 2006–2007, 2008–2009, 2009–2010, and 2010–2011 northern hemisphere influenza campaigns. The presence of Abs against the 1940s era A/Weiss/43 and A/FM/1/47 strains of the A/H1N1 influenza virus was evaluated by using hemagglutination inhibition assays.

immunity and ageing

Antibodies against 1940s era a/H1N1 influenza strains a/Weiss/43 and a/FM/1/47 and heterotypic responses after seasonal vaccination of an elderly Spanish population