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Background  Atrial fibrillation (AF) is the most common arrhythmia in hypertrophic cardiomyopathy (HCM) and is associated with adverse outcomes in HCM patients. Although the left atrial (LA) diameter has consistently been identified as a strong predictor of AF in HCM patients, the relationship between LA dysfunction and AF still remains unclear. The aim of this study is to evaluate the LA function in patients with non-obstructive HCM (NOHCM) utilizing cardiovascular magnetic resonance feature tracking (CMR-FT).    Methods  Thirty-three patients with NOHCM and 28 healthy controls were studied. The global and regional LA function and left ventricular (LV) function were compared between the two groups. The following LA global functional parameters were quantitively analyzed: reservoir function (total ejection fraction [LA total EF], total strain [ε s ], peak positive strain rate [SRs]), conduit function (passive ejection fraction [LA passive EF], passive strain [ε e ], peak early-negative SR [SRe]), and booster pump function (active ejection fraction [LA active EF], active strain [ε a ], peak late-negative SR [SRa]). The LA wall was automatically divided into 6 segments: anterior, antero-roof, inferior, septal, septal-roof and lateral. Three LA strain parameters (ε s , ε e , ε a ) and their corresponding strain rate parameters (SRs, SRe, SRa) during the reservoir, conduit and booster pump LA phases were segmentally measured and analyzed.    Results  The LA reservoir (LA total EF: 57.6 ± 8.2% vs. 63.9 ± 6.4%,  p  < 0.01; ε s : 35.0 ± 12.0% vs. 41.5 ± 11.2%,  p  = 0.03; SRs: 1.3 ± 0.4 s − 1  vs. 1.5 ± 0.4 s − 1 ,  p  = 0.02) and conduit function (LA passive EF: 28.7 ± 9.1% vs. 37.1 ± 10.0%,  p  < 0.01; ε e : 18.7 ± 7.9% vs. 25.9 ± 10.0%,  p  < 0.01; SRe: − 0.8 ± 0.3 s − 1  vs. -1.1 ± 0.4 s − 1 ,  p  < 0.01) were all impaired in patients with NOHCM when compared with healthy controls, while LA booster pump function was preserved. The LA segmental strain and strain rate analysis demonstrated that the ε s , ε e , SRe of inferior, SRs, SRe of septal-roof, and SRa of antero-roof walls (all  p  < 0.05) were all decreased in the NOHCM cohort. Correlations between LA functional parameters and LV conventional function and LA functional parameters and baseline parameters (age, body surface area and NYHA classification) were weak. The two strongest relations were between ε s  and LA total EF( r  = 0.84,  p  < 0.01), ε a  and LA active EF ( r  = 0.83,  p  < 0.01).    Conclusions  Compared with healthy controls, patients with NOHCM have LA reservoir and conduit dysfunction, and regional LA deformation before LA enlargement. CMR-FT identifies LA dysfunction and deformation at an early stage.

journal of cardiovascular magnetic resonance

Quantification of left atrial function in patients with non-obstructive hypertrophic cardiomyopathy by cardiovascular magnetic resonance feature tracking imaging: a feasibility and reproducibility study