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Background  The definition of left ventricular (LV) non-compaction is controversial, and discriminating between normal and excessive LV trabeculation remains challenging. Our goal was to quantify LV trabeculation on cardiovascular magnetic resonance (CMR) images in a genetic mouse model of non-compaction using a dedicated semi-automatic software package and to compare our results to the histology used as a gold standard.    Methods  Adult mice with ventricular non-compaction were generated by conditional trabecular deletion of  Nkx2–5 . Thirteen mice (5 controls, 8 Nkx2–5 mutants) were included in the study. Cine CMR series were acquired in the mid LV short axis plane (resolution 0.086 × 0.086x1mm 3 ) (11.75 T). In a sub set of 6 mice, 5 to 7 cine CMR were acquired in LV short axis to cover the whole LV with a lower resolution (0.172 × 0.172x1mm3). We used semi-automatic software to quantify the compacted mass (M c ), the trabeculated mass (M t ) and the percentage of trabeculation (M t /M c ) on all cine acquisitions .  After CMR all hearts were sliced along the short axis and stained with eosin, and histological LV contouring was performed manually, blinded from the CMR results, and M t , M c  and M t /M c  were quantified. Intra and interobserver reproducibility was evaluated by computing the intra class correlation coefficient (ICC).    Results  Whole heart acquisition showed no statistical significant difference between trabeculation measured at the basal, midventricular and apical parts of the LV. On the mid-LV cine CMR slice, the median M t  was 0.92 mg (range 0.07–2.56 mg), M c  was 12.24 mg (9.58–17.51 mg), M t /M c  was 6.74% (0.66–17.33%). There was a strong correlation between CMR and the histology for M t , M c  and M t / M c  with respectively: r 2  = 0.94 ( p < 0.001 ), r 2  = 0.91 ( p < 0.001 ), r 2  = 0.83 ( p < 0.001 ). Intra- and interobserver reproducibility was 0.97 and 0.8 for M t ; 0.98 and 0.97 for M c ; 0.96 and 0.72 for M t /M c , respectively and significantly more trabeculation was observed in the M c  Mutant mice than the controls.    Conclusion  The proposed semi-automatic quantification software is accurate in comparison to the histology and reproducible in evaluating M c , M t  and M t / M c  on cine CMR.

journal of cardiovascular magnetic resonance

Semi-automatic detection of myocardial trabeculation using cardiovascular magnetic resonance: correlation with histology and reproducibility in a mouse model of non-compaction