English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Many widely used myocardial T 1  mapping sequences use breath-hold acquisitions that limit the precision of calculated T 1  maps. The SAturation-recovery single-SHot Acquisition (SASHA) sequence has high accuracy with robustness against systematic confounders, but has poorer precision compared to the commonly used MOdified Look-Locker Inversion recovery (MOLLI) sequence. We propose a novel method for generating high-contrast SASHA images to enable a robust image registration approach to free-breathing T 1  mapping with high accuracy and precision.    Methods  High-contrast (HC) images were acquired in addition to primary variable flip angle (VFA) SASHA images by collecting an additional 15 k-space lines and sharing k-space data with the primary image. The number of free-breathing images and their saturation recovery times were optimized through numerical simulations. Accuracy and precision of T 1  maps using the proposed SASHA-HC sequence was compared in 10 volunteers at 1.5 T to MOLLI, a breath-hold SASHA-VFA sequence, and free-breathing SASHA-VFA data processed using conventional navigator gating and standard image registration. Free-breathing T 1  maps from 15 patients and 10 volunteers were graded by blinded observers for sharpness and artifacts.    Results  Difference images calculated by subtracting HC and primary SASHA images had greater tissue-blood contrast than the primary images alone, with a 3× improvement for 700 ms TS saturation recovery images and a 6× increase in tissue-blood contrast for non-saturated images. Myocardial T 1 s calculated in volunteers with free-breathing SASHA-HC were similar to standard breath-hold SASHA-VFA (1156.1 ± 28.1 ms vs 1149.4 ± 26.5 ms,  p  >0.05). The standard deviation of myocardial T 1  values using a 108 s free-breathing SASHA-HC (36.2 ± 3.1 ms) was 50 % lower ( p  <0.01) than breath-hold SASHA-VFA (72.7 ± 8.0 ms) and 34 % lower ( p  <0.01) than breath-hold MOLLI (54.7 ± 5.9 ms). T 1  map quality scores in volunteers were higher with SASHA-HC (4.7 ± 0.3 out of 5) than navigator gating (3.6 ± 0.4,  p  <0.01) or normal registration (3.7 ± 0.4,  p  <0.01). SASHA-HC T 1  maps had comparable precision to breath-hold MOLLI using a retrospectively down-sampled 30 s free-breathing acquisition and 30 % higher precision with a 60 s acquisition.    Conclusions  High-contrast SASHA images enable a robust image registration approach to free-breathing T 1  mapping. Free-breathing SASHA-HC provides accurate T 1  maps with higher precision than MOLLI in acquisitions longer than 30 s.    Electronic supplementary material  The online version of this article (doi:10.1186/s12968-016-0267-9) contains supplementary material, which is available to authorized users.

Robust free-breathing SASHA T1 mapping with high-contrast image registration