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Background  Oxidized low-density lipoproteins and scavenger receptors (SRs) play an important role in the formation and development of atherosclerotic plaques. However, little is known about their presence in epicardial adipose tissue (EAT). The objective of the study was to evaluate the mRNA expression of different SRs in EAT of patients with ischemic heart disease (IHD), stratifying by diabetes status and its association with clinical and biochemical variables.    Methods  We analyzed the mRNA expression of SRs ( LOX - 1 ,  MSR1 ,  CXCL16 ,  CD36  and  CL - P1 ) and macrophage markers ( CD68 ,  CD11c  and  CD206 ) in EAT from 45 patients with IHD (23 with type 2 diabetes mellitus (T2DM) and 22 without T2DM) and 23 controls without IHD or T2DM.    Results   LOX - 1 ,  CL - P1 ,  CD68  and  CD11c  mRNA expression were significantly higher in diabetic patients with IHD when compared with those without T2DM and control patients.  MSR1 ,  CXCL16 ,  CD36  and  CD206  showed no significant differences. In IHD patients,  LOX - 1  (OR 2.9; 95% CI 1.6–6.7; P = 0.019) and  CD68  mRNA expression (OR 1.7; 95% CI 0.98–4.5; P = 0.049) were identified as independent risk factors associated with T2DM. Glucose and glycated hemoglobin were also shown to be risk factors.    Conclusions  SRs mRNA expression is found in EAT.  LOX - 1  and  CD68  and were higher in IHD patients with T2DM and were identified as a cardiovascular risk factor of T2DM. This study suggests the importance of EAT in coronary atherosclerosis among patients with T2DM.

Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes