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Background  MUC4 is a membrane-bound mucin that promotes carcinogenetic progression and is often proposed as a promising biomarker for various carcinomas. In this manuscript, we analyzed large scale genomic datasets in order to evaluate  MUC4  expression, identify genes that are correlated with  MUC4  and propose new signatures as a prognostic marker of epithelial cancers.    Methods  Using cBioportal or SurvExpress tools, we studied  MUC4  expression in large-scale genomic public datasets of human cancer (the cancer genome atlas, TCGA) and cancer cell line encyclopedia (CCLE).    Results  We identified 187 co-expressed genes for which the expression is correlated with  MUC4  expression. Gene ontology analysis showed they are notably involved in cell adhesion, cell–cell junctions, glycosylation and cell signaling. In addition, we showed that  MUC4  expression is correlated with  MUC16  and  MUC20 , two other membrane-bound mucins. We showed that MUC4 expression is associated with a poorer overall survival in TCGA cancers with different localizations including pancreatic cancer, bladder cancer, colon cancer, lung adenocarcinoma, lung squamous adenocarcinoma, skin cancer and stomach cancer. We showed that the combination of  MUC4 ,  MUC16  and  MUC20  signature is associated with statistically significant reduced overall survival and increased hazard ratio in pancreatic, colon and stomach cancer.    Conclusions  Altogether, this study provides the link between (i) MUC4 expression and clinical outcome in cancer and (ii) MUC4 expression and correlated genes involved in cell adhesion, cell–cell junctions, glycosylation and cell signaling. We propose the MUC4/MUC16/MUC20 high  signature as a marker of poor prognostic for pancreatic, colon and stomach cancers.    Electronic supplementary material  The online version of this article (10.1186/s12967-018-1632-2) contains supplementary material, which is available to authorized users.

journal of translational medicine

Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas