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Background  Hepatocyte growth factor (HGF)  is a cytokine that has a profound effect on cancer cells by stimulating migration and invasion and acting as an angiogenic factor. In lung cancer, the factor also plays a pivotal role and is linked to a poor outcome in patients. In particular, HGF is known to work in combination with EGF on lung cancer cells. In the present study, we investigated the effect of a traditional Chinese medicine reported in cancer therapies, namely  YangZheng XiaoJi  ( YZXJ ) on lung cancer and on HGF mediated migration and invasion of lung cancer cells.    Methods  Human lung cancer cells, SKMES1 and A549 were used in the study. An extract from the medicine was used. Cell migration was investigated using the EVOS and by ECIS. Cell–matrix adhesion and in vitro invasion were assessed. In vivo growth of lung cancer was tested using an in vivo xenograft tumour model and activation of the HGF receptor in lung tumours by an immunofluorescence method.    Results  Both lung cancer cells increased their migration in response to HGF and responded to  YZXJ  by reducing their speed of migration.  YZXJ  markedly reduced the migration and in vitro invasiveness induced by HGF. It worked synergistically with PHA665752 and SU11274, HGF receptor inhibitors on the lung cancer cells both on HGF receptor activation and on cell functions. A combination of HGF and EGF resulted in a greater increase in cell migration, which was similarly inhibited by  YZXJ,  and in combination with the HGF receptor and EGF receptor inhibitors. In vivo , YZXJ  reduced the rate of tumour growth and potentiated the effects of PHA665752 on tumour growth. It was further revealed that  YZXJ  significantly reduced the degree of phosphorylation of the HGF receptor in lung tumours.    Conclusion   YZXJ  has a significant role in reducing the migration, invasion and in vivo tumour growth of lung cancer and acts to inhibit the migratory and invasive effects induced by HGF and indeed by HGF/EGF. This effect is likely attributed to the inhibition of the HGF receptor activation. These results indicate that  YZXJ  has a therapeutic role in lung cancer and that combined strategy with methods to block HGF and EGF should be considered.    Electronic supplementary material  The online version of this article (doi:10.1186/s12967-015-0639-1) contains supplementary material, which is available to authorized users.

YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells