English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Overexpression of  SLMAP  gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. In this study our primary objective is to explore the role of  SLMAP  gene polymorphisms in the susceptibility of type 2 diabetes (T2DM) with or without diabetic retinopathy (DR) in the Qatari population.    Methods  A total of 342 Qatari subjects (non-diabetic controls and T2DM patients with or without DR) were genotyped for  SLMAP  gene polymorphisms (rs17058639 C > T; rs1043045 C > T and rs1057719 A > G) using Taqman SNP genotyping assay.    Results   SLMAP  rs17058639 C > T polymorphism was associated with the presence of DR among Qataris with T2DM. One-way ANOVA and multiple logistic regression analysis showed  SLMAP  SNP rs17058639 C > T as an independent risk factor for DR development.  SLMAP  rs17058639 C > T polymorphism also had a predictive role for the severity of DR. Haplotype C rs17058639 T rs1043045 A rs1057719  was associated with the increased risk for DR among Qataris with T2DM.    Conclusions  The data suggests the potential role of  SLMAP  SNPs as a risk factor for the susceptibility of DR among T2DM patients in the Qatari population.    Electronic supplementary material  The online version of this article (doi:10.1186/s12967-015-0411-6) contains supplementary material, which is available to authorized users.

Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population