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Background  Whether glutathione S-transferase ( GST ) null polymorphisms, namely  GSTM1  null,  GSTP1  null and  GSTT1  null polymorphisms, influence the risk of coronary artery disease (CAD) or not remains unclear. Thus, the authors performed a meta-analysis to more robustly estimate associations between  GST  null polymorphisms and the risk of CAD by integrating the results of previous publications.    Methods  Medline, Embase, Wanfang, VIP and CNKI were searched comprehensively for eligible studies, and 45 genetic association studies were finally selected to be included in this meta-analysis.    Results  We found that  GSTM1  null polymorphism was significantly associated with the risk of CAD in overall population (OR = 1.37,  p  = 0.003) and mixed population (OR = 1.61,  p  = 0.004),  GSTP1  null polymorphism was significantly associated with the risk of CAD in overall population (OR = 1.23,  p  = 0.03), whereas  GSTT1  null polymorphism was significantly associated with the risk of CAD in overall population (OR = 1.23,  p  = 0.02), Caucasians (OR = 1.23,  p  = 0.02) and East Asians (OR = 1.38,  p  < 0.0001).    Conclusions  This meta-analysis demonstrated that  GSTM1  null,  GSTP1  null and  GSTT1  null polymorphisms were all significantly associated with an increased risk of CAD.

GST null polymorphisms may affect the risk of coronary artery disease: evidence from a meta-analysis