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Otogelin-like protein (encoded by  Otogl ) was highly structural similar to the gelforming mucin proteins. Although human OTOG mutations have been linked to deafness, the biological function of OTOGL in male germ cell development remains enigmatic. In screening 336 patients with non-obstructive azoospermia (NOA), OTOGL displays the high mutant ratio (13.99 %). Then, we examined the expression of OTOGL in developing mouse testes.  Otogl  mRNA and protein are continually expressed in postnatal developing testes from postnatal day 0 (P0) testes to P21 testes exhibiting a decreased trend with the age growth. We thus generated a global  Otogl  knockout mouse (KO) model using the CRISPR/Cas9 technology; however,  Otogl  KO mice displayed normal development and fertility. Further histological analysis of  Otogl  knockout mouse testes revealed that all types of spermatogenic cells are present in  Otogl  KO seminiferous tubules. Together, our study suggested that OTOGL is nonessential for male germ cell development and spermatogenesis.   Supplementary Information  The online version contains supplementary material available at 10.1186/s12958-021-00779-0.

OTOGL, a gelforming mucin protein, is nonessential for male germ cell development and spermatogenesis in mice