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Background  The role of long non-coding RNAs has been extensively appreciated in the contexts of cancer.  Interferon γ-antisense RNA1  ( IFNG-AS1 ) is an lncRNA located near to IFN-γ-encoding ( IFNG ) gene and regulates expression of  IFNG  in Th1 cells.    Methods  In the present study, we evaluated expression of  IFNG  and  IFNG-AS1  in 108 breast samples including tumoral tissues and their adjacent non-cancerous tissues (ANCTs) using real-time PCR.  IFNG-AS1  was significantly upregulated in tumoral tissues compared with ANCTs (expression ratio = 2.23,  P  = 0.03).    Results  Although the expression of  IFNG  was higher in tumoral tissues compared with ANCTs (relative expression = 1.89), it did not reach the level of significance ( P  = 0.07).  IFNG  expression was significantly higher in HER2-negative tumoral tissues compared with HER2-positive ones ( P  = 0.01) and in grade 1 samples compared with grade 2 ones ( P  = 0.03). No other significant difference was found in expressions of genes between other groups.    Conclusion  Significant strong correlations were detected between expression of  IFNG  and  IFNG-AS1  in both tumoral tissues and ANCTs. The present study provides evidences for participation of  IFNG  and  IFNG-AS1  in the pathogenesis of breast cancer and warrants future studies to elaborate the underlying mechanism.

Assessment of expression of interferon γ (IFN-G) gene and its antisense (IFNG-AS1) in breast cancer