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Background  In this study, we aimed to identify a novel extracellular proteinase ADAMTS-18 that could be a potential tumor suppressor gene.    Results  We successfully constructed  Adamts-18  knockout mice with BALB / c background. RT-PCR analysis showed syngeneic mammary tumor cell line 4 T1  per se  has weakly endogenous ADAMTS-18 expression. Orthotopic inoculation of 4 T1 cells within the mammary fat pad of host mice, we found no significant difference in tumor growth and metastasis between  Adamts-18  knockout mice and widetype control.    Conclusions  We did not confirm that ADAMTS-18 in the host tissues is relevant for breast tumor progress in a murine 4 T1 breast cancer model.

ADAMTS-18 in the host tissues exerts little effect on breast tumor progress in a murine 4T1 breast cancer model