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Background  Apolipoprotein E (ApoE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) regulate lipid metabolism. However, the relationship between genetic polymorphisms of  APOE  and  SLCO1B1  and cerebral infarction (CI) remains unclear.    Methods  A total of 938 CI patients and 1028 control participants were included in the study. The rs429358 and rs7412 single nucleotide polymorphisms (SNPs) in the  APOE  gene and rs2306283 and rs4149056 SNPs in the  SLCO1B1  gene were analyzed by fluorescence polymerase chain reaction (PCR).    Results  The genotype ɛ3/ɛ3 was the most common  APOE  genotype, with ɛ3 being the allele with the highest frequency, followed by ɛ4 and ɛ2. Statistically significant differences of genotype ɛ2/ɛ2 (χ 2  = 3.866,  P  = 0.049), ɛ2/ɛ3 (χ 2  = 20.030,  P  < 0.001), ɛ3/ɛ4 (χ 2  = 16.960,  P  < 0.001), and ɛ4/ɛ4 (χ 2  = 4.786,  P  = 0.029) between CI patients and controls were detected. The  SLCO1B1  genotype *1b/*1b and haplotype *1b showed the highest frequency in the study sample. There was no statistically significant difference in the frequencies of  SLCO1B1  genotypes and haplotypes among CI patients comparing with controls. Moreover, ε4 carriers had significantly higher low-density lipoprotein-cholesterol (LDL-C) and apolipoprotein B (Apo-B) and lower apolipoprotein A1 (Apo-A1)/Apo-B levels than ε2 and ε3 carriers, but ε2 carriers showed lower LDL-C and Apo-B and higher Apo-A1/Apo-B than ε3 and ε4 carriers. Further, logistic regression analysis revealed that high LDL-C, high ApoB, smoking, hypertension and the ε4 allele were risks for the presence of CI.    Conclusions  This study indicated that the  APOE  SNPs rs429358 and rs7412 may be associated with susceptibility to cerebral infarction in southern Chinese Hakka population.

lipids in health and disease

The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population