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Background  The  Sst I polymorphism in the apolipoprotein 3 gene ( apoC3 ) has been identified in many ethnic groups. In addition, the S2 allele of the SstI polymorphism is shown to be associated with increased plasma triglyceride (TG) levels. Plasma apoCIII is an important atherogenic factor, which interrupts lipid metabolism and is positively associated with plasma TG levels. However, the existence of the  Sst I polymorphism in the Li ethnic group in China remains to be confirmed. The relationship between the S2 allele of the  Sst I polymorphism and plasma apoCIII or TG and their roles in atherosclerosis are also unknown.    Methods  A cohort of 628 participants was recruited (316 atherosclerotic patients and 312 healthy controls) from both the Li and Han ethnic groups. Blood samples were obtained to evaluate the  Sst I polymorphism in the  apoC3  and lipid profiles. Chi-squared and  t -tests and multiple unconditional logistic regression were employed to analyze the genotypic and allelic frequencies and lipid profiles using SPSS version 20.0 software.    Results  The  Sst I polymorphism in the  apoC3  was identified in the Li ethnic group. The S2 allele and plasma apoCIII and TG levels were associated with the development of atherosclerosis ( P  < 0.01, S2 allele and apoCIII;  P  < 0.05, TG) in the Li ethnic group. The S2 allele was associated with increased plasma apoCIII levels in the atherosclerotic group ( P  < 0.01), but with increased plasma apoCIII and TG levels in control group (both  P  < 0.01). In addition to the increases in the S2 allele frequency and plasma TG and apoCIII levels, atherosclerotic patients in the Li ethnic group also exhibited increased apoB, decreased HDL-C and apoAI and a lower apoAI:apoB ratio (all  P  < 0.01).    Conclusions  Our results indicate that the S2 allele of the  Sst I polymorphism in the  apoC3  gene is associated with plasma apoCIII levels in the Li population. In combination with unfavorable lipid profiles, this might contribute to susceptibility to atherosclerosis.

lipids in health and disease

Association of the S2 allele of the SstI polymorphism in the apoC3 gene with plasma apoCIII interacts with unfavorable lipid profiles to contribute to atherosclerosis in the Li ethnic group in China