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Background  DDX5/p68 RNA helicase is a member of the DEAD (Asp-Glu-Ala-Asp) box proteins. Apart from RNA unwinding, DDX5 is an important transcriptional factor and co-activator in cell proliferation and differentiation.    Findings  Here, we have characterised the role of DDX5 in adipogenesis in 3T3-L1 cells using siRNA mediated suppression. Transient inhibition of  Ddx5  mRNA expression at the start of adipogenesis impairs the differentiation programme even when DDX5 expression is restored later in adipogenesis. However transient suppression of  Ddx5  at the later stages of adipogenesis do not impair adipogenesis or triglyceride accumulation suggesting  Ddx5  expression is dispensable in a mature adipocyte.    Conclusion  These results implicate DDX5 as a crucial factor involved in the complex transcriptional cascade of events that regulate adipogenesis and essential to the initiation of adipogenesis.

DDX5/p68 RNA helicase expression is essential for initiating adipogenesis