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Background  Plasminogen activator inhibitor −2 (PAI-2) is an important molecular that plays a crucial role in vascular homeostasis and constitutes a critical response mechanism to cardiovascular injury, such as atherosclerosis, coronary artery disease (CAD).    Methods  The aim of the current study was to explore the association between the variants in  PAI-2  gene and CAD and its prognoses. The three variants (rs8093048, rs9946657, rs9320032) of the  PAI-2  gene were detected in 407 patients with CAD and 518 control subjects. All patients with CAD underwent one-year follow-up for major adverse cardiac events (MACE).    Results  The frequencies of the TT genotype and T allele of rs8093048 was significantly higher in CAD patients than that in control subjects (7.6 % vs.3.5 %,  P  = 0.003, 28.1 % vs.21.7 %,  P  < 0.001, respectively). Multifactor logistic regression analysis showed that the TT genotype of rs8093048 was a risk factor for CAD (OR = 1.455, 95 % CI: 1.069-1.980,  P  = 0.017). In addition, the follow-up data showed that CAD patients with rs8093048 TT genotype had significantly higher rate of refractory angina and MACE than those with CC or CT genotype ( P  = 0.032,  P  = 0.009, respectively). Cox regression analysis showed that rs8093048 TT genotype was the risk factor for the MACE (Hazard ratio = 5.672, 95 % CI = 1.992-16.152,  P  = 0.001).    Conclusion  We firstly found that the variant of  PAI-2  gene was associated with CAD and recurrent coronary event risk in Chinese Han population, in Xinjiang.

Variant of PAI-2 gene is associated with coronary artery disease and recurrent coronary event risk in Chinese Han population