English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  The beta-3 adrenergic receptor ( β3-AR ) Trp64Arg and uncoupling protein 1 ( UCP1 ) -3826 A > G polymorphisms have been reported to be associated with obesity and/or lipid metabolism in some populations. This study examined the possible association of the  β3-AR  and  UCP1  polymorphisms with overweight/obesity or lipid variation in a Southwest Chinese population.    Methods  A total of 418 Han Chinese (249 overweight/obese and 169 healthy control subjects) in the Chengdu area were studied using PCR-RFLP analysis. Total serum cholesterol (TC) and triglycerides (TGs) were measured using an enzymatic method. High density lipoprotein cholesterol (HDL-C) was determined after sodium phosphotungstate/magnesium chloride precipitation of low-density lipoproteins by polyvinyl sulfate. Serum apolipoproteins were quantified by radial immunodiffusion.    Results  The genotype and allele frequencies of the  β3-AR  Trp64Arg and  UCP1  -3826 A > G polymorphisms in overweight/obese subjects exhibited no significant differences compared to the controls. However, subjects carrying the  β3-AR  TrpTrp genotype and  UCP1  AG genotype had higher TG levels than those carrying the Arg allele and AA genotype, respectively (P < 0.05), while controls carrying the  β 3 -AR  Arg allele had significantly higher TC and apo AII concentrations than those carrying the TrpTrp genotype (P < 0.05). Additionally, subjects carrying the  UCP1  AG genotype exhibited elevated apo C-II and apo C-III levels compared to those carrying the AA genotype (P < 0.05). We were unable to find an association of the  UCP1  and  β3-AR  polymorphisms with low HDL-cholesterolemia in the overweight/obese subjects.    Conclusions  The present study provides evidence that the  β3-AR  Trp64Arg and  UCP1  -3826 A > G polymorphisms are associated with TG levels in overweight/obese Chinese subjects and that the two polymorphisms are also associated with certain lipid and apolipoprotein variations, depending on BMI. However, these polymorphisms are not associated with overweight/obesity or low HDL-cholesterolemia in a Chinese population from the Chengdu area.

lipids in health and disease

Effect of the beta-3 adrenergic receptor Trp64Arg and uncoupling protein 1–3826 A &gt; G genotypes on lipid and apolipoprotein levels in overweight/obese and non-obese Chinese subjects