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Background  The objective of this study was to investigate the expression and clinical role of 14 genes previously shown to be associated with chemotherapy response and/or progression-free survival in a smaller series of ovarian serous carcinoma effusions.    Methods  Advanced-stage serous ovarian carcinoma effusions (n = 150) were analyzed for mRNA expression of  AKR1C1 ,  ABCA4 ,  ABCA13 ,  ABCB10 ,  BIRC6 ,  CASP9 ,  CIAPIN1 ,  FAS ,  MGMT ,  MUTYH ,  POLH ,  SRC ,  TBRKB  and  XPA  using quantitative real-time PCR. mRNA expression was studied for association with clinicopathologic parameters, including chemotherapy response and survival.    Results   ABCA4  mRNA expression was significantly related to better (complete) chemotherapy response at diagnosis in the entire cohort (p = 0.018), whereas higher  POLH  mRNA levels were significantly related to better chemoresponse at diagnosis in analysis to 58 patients with pre-chemotherapy effusions treated with standard chemotherapy (carboplatin + paclitaxel; p = 0.023). In univariate survival analysis for patients with pre-chemotherapy effusions (n = 77),  CIAPIN1  mRNA expression was significantly related to shorter overall (p = 0.007) and progression-free (p = 0.038) survival, whereas  ABCA13  mRNA expression was significantly related to shorter OS (p = 0.024). Higher  CIAPIN1  mRNA expression was an independent marker of poor overall survival in Cox multivariate analysis (p = 0.044).    Conclusions  Our data identify  ABCA4  and  POLH  as markers of better chemotherapy response in metastatic serous carcinoma.  CIAPIN1  and  ABCA13  may be novel markers of poor outcome in pre-chemotherapy serous carcinoma effusions.

CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma