English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background   Streptococcus pyogenes  is an uncommon pathogen of purpura fulminans, and the pathogenesis of  S. pyogenes -purpura fulminans remains unclear because of paucity of cases. We reported a pediatric case of  S. pyogenes -purpura fulminans with literature review of the disease.    Case presentation  A 3-year-old boy showed limping, lethargy and acral gangrene within 24 h. A diagnosis of  S. pyogenes -purpura fulminans was made for bacterial isolation from throat and peripheral blood. Intensive therapy led to a survival with amputation of the left distal metatarsal bone, and normal development. The isolated M12 carried no mutation of  csrS/R  or  rgg . Thrombophilia or immunodeficiency was excluded.    Discussion  Twelve-reported cases (9 pediatric and 3 elderly) of  S. pyogenes -purpura fulminans started with shock and coagulopathy. Five patients age < 8 years had no underlying disease and survived. One youngest and two immunocompromised patients died.    Conclusion   Streptococcus pyogenes -acute infectious purpura fulminans is a distinctive rare form of aggressive GAS infections.

Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection