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Background  Diarrheagenic  Escherichia coli  are associated with infantile diarrhea in the developing countries. The present study was conducted to determine the occurrence and antimicrobial resistance pattern of enteropathogenic and enteroinvasive  E. coli  associated with diarrhoea among the paediatric patients.    Methods  A total of 262 stool samples were collected from children with and without diarrhea from Mizoram, Northeast India.  E. coli  were isolated and subjected to multiplex PCR to detect virulent genes of EPEC ( eaeA  and  bfpA ) and EIEC ( ial ). Isolates were subjected to antimicrobial sensitivity assay using disc diffusion method. Selected  eaeA  genes were sequenced for identification and genetic relationship.    Results  A total of 334  E. coli  was isolated, of which 17.37% were carrying at least one virulent gene. Altogether, 14.97 and 2.40% isolates were categorized as EPEC and EIEC, respectively. Among the DEC isolates, 4.79% were EPEC and 7.78% were EIEC. A total of 8 (2.40%) isolates were EIEC ( ial +), of which 6 (1.80%) and 2 (0.60%) were from diarrhoeic and non-diarrhoeic patients, respectively. A total of 24 (41.40%) DEC isolates were MDR (resistance against ≥5 antimicrobials).    Conclusions  A high frequency of EPEC pathotypes associated with paediatric diarrhea was observed in Mizoram, Northeast India and majority of the isolates are resistant to antibiotics with a high frequency of MDR, which is a matter of concern to the public health. This also raises an alarm to the world communities to monitor the resistance pattern and analyse in a global scale to combat the problems of resistance development.

annals of clinical microbiology and antimicrobials

Prevalence of multi drug resistant enteropathogenic and enteroinvasive Escherichia coli isolated from children with and without diarrhea in Northeast Indian population