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Background  The purpose of this study was to evaluate the prevalence of  Chlamydia trachomatis ,  Neisseria gonorrhoeae ,  Mycoplasma genitalium  and  Ureaplasma urealyticum  infections in infertile men that consulted our outpatient departments using a novel simultaneous amplification testing (SAT) that is RNA-detection based. The possible impact of  C. trachomatis ,  N. gonorrhoeae ,  M. genitalium  and  U. urealyticum  infections on semen parameters was also noted in the present study.    Methods  A total of 2607 males that were diagnosed with infertility were included in this study.  C. trachomatis ,  N. gonorrhoeae ,  M. genitalium  and  U. urealyticum  infections were detected in the urine samples using SAT method. Related data, including semen parameters and age as well as  C. trachomatis ,  N. gonorrhoeae ,  M. genitalium  and  U. urealyticum  infections were collected and analyzed.    Results  A total of 51 and 1418 urine samples were found positive for  M. genitalium  RNA and  U. urealyticum  RNA, respectively, while the prevalence of  C. trachomatis  and  N. gonorrhoeae  was relatively lower. Men with positive  M. genitalium  RNA and  U. urealyticum  RNA had higher sperm DNA fragmentation index (DFI) while the comparisons of other semen parameters yielded nonsignificant results between the RNA positive and negative group. A multivariate linear regression analysis revealed that  U. urealyticum  and  M. genitalium  infections posed significant factors of DFI (adjusted R 2  = 46.2%).    Conclusions  Our study suggested a relative high prevalence of  U. urealyticum  and  M. genitalium  infection based on this novel SAT detection method.  U. urealyticum  and  M. genitalium  infection could possibly impair male fertility potential through promoting sperm DNA damage.

annals of clinical microbiology and antimicrobials

Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Ureaplasma urealyticum infections using a novel isothermal simultaneous RNA amplification testing method in infertile males