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Background and aim of work    Acinetobacter baumannii  is known for nosocomial outbreaks worldwide. In this study, we aimed to investigate the antibiotic susceptibility patterns and the clonal relationship of  A. baumannii  isolates from the intensive care unit (ICU) of an Egyptian hospital.    Methods  In the present study, 50 clinical isolates of multidrug resistant (MDR)- A. baumannii  were obtained from patients admitted into the ICU from June to December 2015. All isolates were analyzed for antimicrobial susceptibilities. Multiplex PCR was performed to detect genes encoding oxacillinase genes ( bla   OXA-51 -like,  bla   OXA-23 -like,  bla   OXA-24 -like, and  bla   OXA-58 -like). Multilocus sequence typing (MLST) based on the seven-gene scheme ( gltA, gyrB, gdhB, recA, cpn60, gpi, rpoD ) was used to examine these isolates.    Results  All  A. baumannii  clinical isolates showed the same resistance pattern, characterized by resistance to most common antibiotics including imipenem (MIC ≥ 8μ/mL), with the only exception being colistin. Most isolates were positive for  bla   OXA-51 -like and  bla   OXA-23 -like (100 and 96%, respectively); however,  bla   OXA-24 -like and  bla   OXA-58 -like were not detected. MLST analysis identified different sequence types (ST195, ST208, ST231, ST441, ST499, and ST723) and a new sequence type (ST13929) with other sporadic strains.    Conclusions  MDR  A. baumannii  strains harboring  bla   OXA-23 -like genes were widely circulating in this ICU. MLST was a powerful tool for identifying and epidemiologically typing our strains. Strict infection control measures must be implemented to contain the worldwide spread of MDR  A. baumannii  in ICUs.

The emergence of a novel sequence type of MDR Acinetobacter baumannii from the intensive care unit of an Egyptian tertiary care hospital