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Background  To investigate the drug resistant gene profiles and molecular typing of  Acinetobacter baumannii  isolates collected from clinical specimens in a comprehensive hospital, Jiangsu province.    Methods  This study included 120 patients in a comprehensive hospital with drug-resistant  A. baumannii  infections on clinical specimens from October 2011 to December 2013. Antibiotic susceptibility test was determined by Vitek 2 Compact system.  OXA -51,  OXA -23,  OXA -24,  OXA -58,  VIM ,  IMP ,  SHV ,  GES ,  TEM ,  AmpC ,  qacE Δ1- sul 1,  intI  l,  CarO ,  aac (6′)- Ib , and  aac(6′)-II  were analyzed by PCR. The analysis of molecular typing for 50 multidrug resistant  A. baumannii  isolates was performed by PFGE.    Results  A total of 64(53%) isolates were multidrug-resistant  A.baumannii . The antibiotic susceptibility tests showed that the resistant rates to common antibiotics of mutidrug-resistant  A. baumannii  were extremely high, most of which over 60%. One hundred and ten isolates harbored  OXA-51  (91.7%), 100 for  OXA-23 (83.3%), 103 for  VIM-1 (85.8%), 90 for  AmpC (75.00%), 50 for  aac(6′)-Ib (41.7%), 77 for the loss of  CarO  (64.2%), 85 for  intl1 (70.8%), and 64 for  qacE Δ 1-sul1 (53.33%), while  OXA-24  was undetected. Fifty multidrug-resistant  A. baumannii  isolates belong to 14 clones according to the PFGE DNA patterns. Main clone A includes 24 isolates, while clone B and clone C includes 6 and 9 isolates, respectively and others with no common source identified.    Conclusion  There is high morbidity of  A. baumannii  infections in the hospital, especially in ICU and sputum is the most common sample type.The mainly drug-resistant genes of  A. baumannii  are  OXA-51 ,  OXA-23 , and  VIM-1  in the hospital. Clonal dissemination provides evidence for the prevalence of multidrug-resistant  A. baumannii  among clinical isolates. It is suggested that there is an urgent need for effective control and prevention measures.

An investigation of drug-resistant Acinetobacter baumannii infections in a comprehensive hospital of East China