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Background  This study was conducted to explore new approaches of animal biocontrol via biological control feed.    Method  White rats were subjected to 140 highly lytic designed phages specific against  E. coli . Phages were fed via drinking water, oral injection, and vegetable capsules. Phage feeding was applied by 24 h feeding with 11d monitoring and 20d phage feeding and monitoring. Group of rats received external pathogenic  E. coli  and another group did not, namely groups A and B.    Results  Phage feeding for 20d via vegetable capsules yielded the highest reduction of fecal  E. coli , 3.02 and 4.62 log, in rats group A and B respectively. Second best, feeding for 20d via drinking water with alkali yielded 2.78 and 4.08 log in rats groups A and B respectively. The peak reduction in  E. coli  output was 5–10 d after phage feeding. Phage control declined after 10 th  day of feeding.    Conclusions  The use of cocktail of designed phages succeeded in suppressing flora or external  E. coli . The phage feed biocontrol is efficient in controlling  E. coli  at the pre-harvest period, precisely at the 6 th -8 th  day of phage feeding when the lowest  E. coli  output found.

Novel approach of using a cocktail of designed bacteriophages against gut pathogenic E. colifor bacterial load biocontrol