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Background and objectives  NF-kB, SIRT1 and systemic inflammation factors including hs-CRP, IL-6 and TNF-α accelerate atherosclerosis pathogenesis. Our purpose was to evaluate the effect of daily supplementation of three-gram cinnamon on plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α among type 2 diabetes patients.    Subjects and methods  A randomized, double blind, and controlled clinical trial was performed with 44 adult patients who were 25 to 70 years old with type 2 diabetes, randomized to two intervention ( n  = 22) and control ( n  = 22) groups differing by daily three grams cinnamon supplementation and placebo for 8 weeks, respectively. The plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α were measured by ELISA assay at the beginning and end of the study.    Results  After 8-week intervention, 39 subjects ( n  = 20 in the cinnamon and  n  = 19 in the placebo groups) ended up the trial. It was not observed significant difference in levels of hs-CRP ( P  = 0.29), TNF-α ( P  = 0.27), IL-6 ( P  = 0.52), and Sirtuin-1 ( P  = 0.51) in between group comparison. While, the result showed significant difference in levels of NF-kB ( P  = 0.02) between groups. As well as, in among group comparison, there was not observed significant differences except in hs-CRP ( P  = 0.008) in placebo group.    Conclusions  This study elucidated that cinnamon supplementation has no beneficial effects in reduction of NF-kB, SIRT1, hs-CRP, IL-6 and TNF-α levels in type 2 diabetes patients which have a considerable role in development of atherogenesis.

nutrition journal

Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial