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Background   Plasmodium falciparum  is responsible for the vast majority of (severe) clinical malaria cases in most African settings. Other  Plasmodium  species often go undiagnosed but may still have clinical consequences.    Case presentation  Here, five cases of  Plasmodium malariae  infections from Eastern Uganda (aged 2–39 years) are presented. These infections were all initially mistaken for  P. falciparum,  but  Plasmodium  schizonts (up to 2080/µL) were identified by microscopy. Clinical signs included history of fever and mild anaemia.    Conclusion  These findings highlight the importance of considering non-falciparum species as the cause of clinical malaria. In areas of intense  P. falciparum  transmission, where rapid diagnostic tests that detect only  P. falciparum  antigens are commonly used, non-falciparum malaria cases may be missed.

Plasmodium malariae infections as a cause of febrile disease in an area of high Plasmodium falciparum transmission intensity in Eastern Uganda