English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  The analysis of single nucleotide polymorphism (SNPs) in drug-resistance associated genes is a commonly used strategy for the surveillance of anti-malarial drug resistance in populations of parasites. The present study was designed and performed to provide genetic epidemiological data of the prevalence of N86Y-Y184F-D1246Y SNPs in  Plasmodium falciparum  multidrug resistance 1 ( pfmdr1 ) in the malaria hotspot of Northern Nigeria.    Methods   Plasmodium falciparum -positive blood samples on Whatman-3MM filter papers were collected from 750 symptomatic patients from four states (Kano, Kaduna, Yobe and Adamawa) in Northern Nigeria, and genotyped via BigDye (v3.1) terminator cycle sequencing for the presence of three SNPs in  pfmdr1 . SNPs in  pfmdr1  were used to construct NYD, NYY, NFY, NFD, YYY, YYD, YFD and YFY haplotypes, and all data were analysed using Pearson Chi square and Fisher’s exact (FE) tests.    Results  The prevalence of the  pfmdr1  86Y allele was highest in Kaduna (12.50%,  2  = 10.50, P = 0.02), whilst the 184F allele was highest in Kano (73.10%,  2  = 13.20, P = 0.00), and the  pfmdr1  1246Y allele was highest in Yobe (5.26%,  2  = 9.20, P = 0.03). The NFD haplotype had the highest prevalence of 69.81% in Kano ( 2  = 36.10, P = 0.00), followed by NYD with a prevalence of 49.00% in Adamawa, then YFD with prevalence of 11.46% in Kaduna. The YYY haplotype was not observed in any of the studied states.    Conclusion  The present study suggests that strains of  P. falciparum  with reduced sensitivity to the lumefantrine component of AL exist in Northern Nigeria and predominate in the North-West region.

malaria journal

Plasmodium falciparum multidrug resistance gene-1 polymorphisms in Northern Nigeria: implications for the continued use of artemether-lumefantrine in the region