English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Several refugee settlements in Bangladesh have provided housing and medical care for the forcibly-displaced Myanmar nationals (FDMN, also known as Rohingya) population. The identification of malaria infection status in the refugee settlements is useful in treating infected persons and in developing malaria prevention recommendations. Assays for  Plasmodium  antigens and human IgG against  Plasmodium  parasites can be used as indicators to determine malaria infection status and exposure.    Methods  Dried blood spot (DBS) samples (N = 1239) from a household survey performed April–May 2018 in three settlements in Cox’s Bazar district, Bangladesh were utilized for a sample population of children from ages 1–14 years of age. The samples were tested using a bead-based multiplex antigen assay for presence of the pan- Plasmodium  antigen aldolase as well as  Plasmodium falciparum  histidine rich protein 2 (HRP2). A bead-based multiplex assay was also used to measure human IgG antibody response to  P. falciparum, Plasmodium malariae,  and  Plasmodium vivax  merozoite surface protein 1 antigen (MSP1) isoforms, and  P. falciparum  antigens LSA1, CSP, and GLURP-R0.    Results  There were no detectable  Plasmodium  antigens in any samples, suggesting no active malaria parasite infections in the tested children. IgG seroprevalence was highest to  P. vivax  (3.1%), but this was not significantly different from the percentages of children antibody responses to  P. falciparum  (2.1%) and  P. malariae  (1.8%). The likelihood of an anti- Plasmodium  IgG response increased with age for all three malaria species. Evidence of exposure to any malaria species was highest for children residing 8–10 months in the settlements, and was lower for children arriving before and after this period of time.    Conclusions  Absence of  Plasmodium  antigen in this population provides evidence that children in these three Bangladeshi refugee settlements did not have malaria at time of sampling. Higher rates of anti-malarial IgG carriage from children who were leaving Myanmar during the malaria high-transmission season indicate these migrant populations were likely at increased risk of malaria exposure during their transit.

Screening for malaria antigen and anti-malarial IgG antibody in forcibly-displaced Myanmar nationals: Cox’s Bazar district, Bangladesh, 2018