English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Background  Malaria remains a very important public health problem in Ethiopia. Currently, only  Plasmodium falciparum  and  Plasmodium vivax  are considered in the malaria diagnostic and treatment policies. However, the existence and prevalence of  Plasmodium ovale  spp. and  Plasmodium malariae  in Ethiopia have not been extensively investigated. The objective of this study was to use a multiplex IgG antibody detection assay to evaluate evidence for exposure to any of these four human malaria parasites among asymptomatic individuals.    Methods  Dried blood spots (DBS) were collected from 180 healthy study participants during a 2016 onchocerciasis survey in the Jimma Zone, southwest Ethiopia. IgG antibody reactivity was detected using a multiplex bead assay for seven  Plasmodium  antigens:  P. falciparum  circumsporozoite protein (CSP),  P. falciparum  apical membrane antigen-1 (AMA1),  P. falciparum  liver stage antigen-1 (LSA1), and homologs of the merozoite surface protein-1 (MSP1)-19kD antigens that are specific for  P. falciparum ,  P. vivax ,  P. ovale  spp. and  P. malariae.Results  One hundred six participants (59%) were IgG seropositive for at least one of the  Plasmodium  antigens tested. The most frequent responses were against  P. falciparum  AMA1 (59, 33%) and  P. vivax  (55, 28%). However, IgG antibodies against  P. ovale  spp. and  P. malariae  were detected in 19 (11%) and 13 (7%) of the participants, respectively, providing serological evidence that  P. malariae  and  P. ovale  spp., which are rarely reported, may also be endemic in Jimma.    Conclusion  The findings highlight the informative value of multiplex serology and the need to confirm whether  P. malariae  and  P. ovale  spp. are aetiologies of malaria in Ethiopia, which is critical for proper diagnosis and treatment.

Sero-identification of the aetiologies of human malaria exposure (Plasmodium spp.) in the Limu Kossa District of Jimma Zone, South western Ethiopia