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Background  Malaria is one of the most life-threatening health problems worldwide and treatment has been compromised by drug resistance. Identifying lead molecules from natural products might help to find better anti-malarial drugs, since those obtained from natural sources are still effective against malarial parasites. This study aimed at investigating the in vivo antiplasmodial activity of crude extract of the leaves of  Ajuga remota  together with its safety in mice models.    Methods  In vivo parasite growth inhibitory effect of crude extract was assessed in mice inoculated with  Plasmodium berghei  (ANKA strain). The in vivo antiplasmodial activity of the test extract was performed against early infection (4-day suppressive test), curative effect against established infection and prophylactic effect against residual infection. Acute and sub-acute toxicity were carried out according to OECD guidelines.    Results  In vivo parasite growth inhibition effect of hydroethanolic crude extract of  A. remota  was evaluated at 30, 50 and 100 mg/kg dose levels. It suppressed parasitaemia by 77.34% at 100 mg/kg dose level in the 4-day test. In curative and prophylactic potential tests, it suppressed parasitaemia by 66.67 and 59.66% at 100 mg/kg dose level, respectively. In vivo toxicity tests revealed no toxicity. All parasitaemia suppressions were statistically significant at P < 0.05 as compared to the vehicle-treated group. The crude extract also prolonged survival time in a dose dependent manner.    Conclusions  The investigation results suggest that the leave extract of  Ajuga remota  possesses antimalarial activity.

In vivo antiplasmodial activity and toxicological assessment of hydroethanolic crude extract of Ajuga remota