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Background  This study was part of the work to prepare for a cluster-randomized controlled trial to evaluate the effect of combining indoor residual spraying and long-lasting insecticidal nets on malaria incidence. A pilot study was done to estimate the variations of malaria incidence among villages, combined with entomological collections and an assessment of susceptibility to insecticides in malaria vectors.    Methods  A cohort of 5309 residents from four  kebeles  (the lowest government administrative unit) in 996 households was followed from August to December 2013 in south-central Ethiopia. Blood samples were collected by a finger prick for a microscopic examination of malaria infections. A multilevel mixed effect model was applied to measure the predictors of malaria episode. Adult mosquitoes were collected using light traps set indoors close to a sleeping person, pyrethrum spray sheet catches and artificial outdoor pit shelters. Enzyme-linked immunosorbent assays were used to detect the sources of mosquito blood meals, while mosquito longevity was estimated based on parity. The World Health Organization’s tube bioassay test was used to assess the insecticide susceptibility status of malaria vectors to pyrethroids and carbamates.    Results  The average incidence of malaria episode was 4.6 per 10,000 person weeks of observation. The age group from 5 to 14 years (IRR = 2.7; 95 % CI 1.1–6.6) and  kebeles  near a lake or river (IRR = 14.2, 95 % CI 3.1–64) were significantly associated with malaria episode. Only 271 (27.3 %) of the households owned insecticide-treated nets. Of 232 adult  Anopheles  mosquitoes collected,  Anopheles arabiensis  (71.1 %) was the predominant species. The average longevity of  An. arabiensis  was 14 days (range: 7–25 human blood index days). The overall human blood index (0.69) for  An. arabiensis  was higher than the bovine blood index (0.38). Statistically significant differences in  Anopheline  mosquitoes abundance were observed between the  kebeles  (P = 0.001).  Anopheles arabiensis  was susceptible to propoxur, but resistant to pyrethroids. However,  An. pharoensis  was susceptible to all pyrethroids and carbamates tested.    Conclusions  This study showed a high variation in malaria incidence and  Anopheles  between  kebeles.  The observed susceptibility of the malaria vectors to propoxur warrants using this insecticide for indoor residual spraying, and the results from this study will be used as a baseline for the trial.

malaria journal

Malaria incidence and entomological findings in an area targeted for a cluster-randomized controlled trial to prevent malaria in Ethiopia: results from a pilot study