English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Development of resistance against the frontline anti-malarial drugs has created an alarming situation, which requires intensive drug discovery to develop new, more effective, affordable and accessible anti-malarial agents.    Methods  Inspired by their ethnobotanical reputation for being effective against febrile diseases, antiplasmodial potential of ethyl acetate extracts (EAE) and methanol extracts (ME) of 17 medicinal plants collected from the Eastern Ghats of South India and Buchpora, North India were explored against  Plasmodium falciparum in vitro  using the SYBR Green assay. The results were validated both by confirmation that the fall in fluorescence signal was not due to quenching effects mediated by phytochemical extracts and by Giemsa-stained microscopy.    Results  Using EAE or ME, promising antiplasmodial activity (IC 50  Pf 3D7 ≤ 20 μg/ml), was seen in  Aerva lanata  (Whole aerial parts-EAE),  Anisomeles malabarica  (Leaf-EAE) , Anogeissus latifolia  (bark-EAE),  Cassia alata  (leaves-EAE),  Glycyrrhiza glabra  (root-EAE),  Juglans regia  (seed-ME),  Psidium guajava  (leaf-ME and EAE) and  Solanum xanthocarpum  (Whole aerial parts-EAE). EAEs from leaves of  Couroupita guianensis ,  Euphorbia hirta ,  Pergularia daemia, Tinospora cordifolia  and  Tridax procumbens  as also ME from  Ricinus communis  (leaf and seed) showed good antiplasmodial activity ( Pf  3D7 IC 50  21 - 40 μg/ml). Moderate activity ( Pf  3D7 IC 50 : 40–60 μg/mL) was shown by the leaf EAEs of  Cardiospermum halicacabum ,  Indigofera tinctoria  and  Ricinus communis  while the remaining extracts showed marginal ( Pf  3D7 IC 50  60 to >100 μg/ml) activities. The promising extracts showed good resistance indices (0.41 – 1.4) against the chloroquine resistant INDO strain of  P. falciparum  and good selectivity indices (3 to > 22.2) when tested against the HeLa cell line.    Conclusion  These results provide validity to the traditional medicinal usage of some of these plants and further make a case for activity-guided purification of new pharmacophores against malaria.    Electronic supplementary material  The online version of this article (doi:10.1186/s12936-015-0564-z) contains supplementary material, which is available to authorized users.

Evaluation of antiplasmodial activity of medicinal plants from North Indian Buchpora and South Indian Eastern Ghats