English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  There is mounting evidence that demonstrated the association of aberrant  NEDD4L  expression with diverse human cancers. However, the expression pattern and clinical implication of  NEDD4L  in acute myeloid leukemia (AML) remains poorly defined.    Methods  We systemically determined  NEDD4L  expression with its clinical significance in AML by both public data and our research cohort. Moreover, biological functions of  NEDD4L  in leukemogenesis were further tested by in vitro experiments.    Results  By the public data, we identified that low  NEDD4L  expression was correlated with AML among diverse human cancers. Expression of  NEDD4L  was remarkably decreased in AML compared with controls, and was confirmed by our research cohort. Clinically, low expression of  NEDD4L  was correlated with greatly lower age, higher white blood cells, and higher bone marrow/peripheral blood blasts. Moreover,  NEDD4L  underexpression was positively correlated with normal karyotype,  FLT3  and  NPM1  mutations, but negatively associated with complex karyotype and  TP53  mutations. Importantly, the association between  NEDD4L  expression and survival was also discovered in cytogenetically normal AML patients. Finally, a number of 1024 RNAs and 91 microRNAs were identified to be linked to  NEDD4L  expression in AML. Among the negatively correlated microRNAs,  miR-10a  was also discovered as a microRNA that may directly target  NEDD4L . Further functional studies revealed that  NEDD4L  exhibited anti-proliferative and pro-apoptotic effects in leukemic cell line K562.    Conclusions  Our findings indicated that  NEDD4L  underexpression, as a frequent event in AML, was associated with genetic abnormalities and prognosis in AML. Moreover,  NEDD4L  expression may be involved in leukemogenesis with potential therapeutic target value.    Supplementary Information  The online version contains supplementary material available at 10.1186/s12935-021-02327-7.

Distinct associations of NEDD4L expression with genetic abnormalities and prognosis in acute myeloid leukemia