English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  The aim of this study was to investigate the association between telomerase reverse transcriptase ( TERT ) gene polymorphisms and acute myeloid leukemia (AML) susceptibility in a Chinese Han population.    Methods  A total of 102 AML patients and 108 healthy controls were enrolled in this case–control study.  TERT  gene rs2853669 and rs2736100 polymorphisms were genotyped via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Chi-square test was applied to compare polymorphism distributions between case and control groups. The strength of the association between  TERT  gene polymorphisms and AML susceptibility was evaluated utilizing odds ratio (OR) with corresponding 95% confidence interval (CI).    Results  CC genotype and C allele of rs2736100 polymorphism were more frequent in AML patients ( P  < 0.05), and individuals carrying CC genotype showed higher risk of suffering from AML (OR = 2.632, 95% CI 1.129–6.133). But for rs2853669 polymorphism, no significant differences were detected in either genotype or allele distributions between groups ( P  > 0.05).    Conclusions  This study suggested a positive association between  TERT  gene rs2736100 polymorphism and AML susceptibility in Chinese Han population.

Association between TERT gene polymorphisms and acute myeloid leukemia susceptibility in a Chinese population: a case–control study