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Background Chest computed tomography (CT) is a widely used method to assess morphological and dynamic abnormalities in chronic obstructive pulmonary disease (COPD). The small pulmonary vascular cross-section (CSA), quantitatively extracted from volumetric CT, is a reliable indicator for predicting pulmonary vascular changes. CSA is associated with the severity of symptoms, pulmonary function tests (PFT) and emphysema and in COPD patients the severity increases over time. We analyzed the correlation longitudinal changes in pulmonary vascular parameters with clinical parameters in COPD patients. Materials and methods A total of 288 subjects with COPD were investigated during follow up period up to 6 years. CT images were classified into five subtypes from normal to severe emphysema according to percentage of low-attenuation areas less than -950 and -856 Hounsfield units (HU) on inspiratory and expiratory CT (LAA-950, LAA-856 exp ). Total number of vessels (N total ) and total number of vessels with area less than 5 mm 2  (N &lt;5 mm ) per 1 cm 2  of lung surface area (LSA) were measured at 6 mm from the pleural surface. Results N total /LSA and N &lt;5 mm /LSA changed from 1.16 ± 0.27 to 0.87 ± 0.2 and from 1.02 ± 0.22 to 0.78 ± 0.22, respectively, during Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage progression. Both parameters changed from normal to severe emphysema according to CT subtype from 1.39 ± 0.21 to 0.74 ± 0.17 and from 1.18 ± 0.19 to 0.67 ± 0.15, respectively. LAA-950 and LAA-856exp were negatively correlated with N total /LSA (r = − 0.738, − 0.529) and N &lt;5 mm  /LSA (r = − 0.729, -− .497). On the other hand, pulmonary function test (PFT) results showed a weak correlation with N total /LSA and N &lt;5 mm /LSA (r = 0.205, 0.210). The depth in CT subtypes for longitudinal change both N total /LSA and N &lt;5 mm /LSA was (− 0.032, − 0.023) and (− 0.027) in normal and SAD, respectively. Conclusions Quantitative computed tomography features faithfully reflected pulmonary vessel alterations, showing in particular that pulmonary vascular alteration started.

Quantitative assessment the longitudinal changes of pulmonary vascular counts in chronic obstructive pulmonary disease