English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Obesity is a risk factor for the development of asthma. In patients with obesity the diagnosis of asthma is often based on symptoms, but without objective measurements. Nevertheless, obesity-associated asthma is recognized as a distinct asthma phenotype. Therefore, this study explores lung function and symptoms in asthma patients with and without obesity.    Methods  The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort study with 6671 participants (aged 45–65 years) of whom 472 had asthma. Of this latter group, linear regression analysis was used to examine differences in lung function and symptoms between asthma patients with ( n  = 248) and without obesity ( n  = 224), and between asthma patients with and without increased Fe NO . Analyses were adjusted for confounders.    Results  Asthma patients with obesity had lower predicted FEV 1  and FVC values than patients without obesity [adjusted mean difference (MD) -3.3% predicted, 95% CI -6.5, −0.2; adjusted MD −5.0% predicted, 95% CI -7.8, −2.1]. The prevalence of symptoms was higher in patients with obesity. Asthma patients with obesity and with increased Fe NO  had lower FEV 1  and FEV 1 /FVC values compared with those with low Fe NO  (adjusted MD −6.9% predicted, 95% CI -11.7, −2.0; −2.4%, 95% CI -4.6, −0.2).    Conclusion  Asthma patients with obesity had lower FEV 1  and FVC values than patients without obesity. This suggests that patients with obesity have restrictive lung function changes, rather than obstructive changes. Asthma patients with obesity and increased Fe NO  showed more obstructive changes. Fe NO  might help to identify patients with eosinophilic inflammation-driven asthma, whereas patients with low Fe NO  might have an obesity-associated asthma phenotype in which symptoms are partly caused by the obesity.    Electronic supplementary material  The online version of this article (10.1186/s12931-017-0684-9) contains supplementary material, which is available to authorized users.

Pulmonary function, exhaled nitric oxide and symptoms in asthma patients with obesity: a cross-sectional study