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Background  In acute respiratory respiratory distress syndrome (ARDS) a sustained mismatch of alveolar ventilation and perfusion (V A /Q) impairs the pulmonary gas exchange. Measurement of endexpiratory lung volume (EELV) by multiple breath-nitrogen washout/washin is a non-invasive, bedside technology to assess pulmonary function in mechanically ventilated patients. The present study examines the association between EELV changes and V A /Q distribution and the possibility to predict V A /Q normalization by means of EELV in a porcine model.    Methods  After approval of the state and institutional animal care committee 12 anesthetized pigs were randomized to ARDS either by bronchoalveolar lavage ( n  = 6) or oleic acid injection ( n  = 6). EELV, V A /Q ratios by multiple inert gas elimination and ventilation distribution by electrical impedance tomography were assessed at healthy state and at five different positive endexpiratory pressure (PEEP) steps in ARDS (0, 20, 15, 10, 5 cmH 2 O; each maintained for 30 min).    Results  V A /Q, EELV and tidal volume distribution all displayed the PEEP-induced recruitment in ARDS. We found a close correlation between V A /Q < 0.1 (representing shunt and low V A /Q units) and changes in EELV (spearman correlation coefficient −0.79). Logistic regression reveals the potential to predict V A /Q normalization (V A /Q < 0.1 less than 5%) from changes in EELV with an area under the curve of 0.89 with a 95%-CI of 0.81–0.96 in the receiver operating characteristic. Different lung injury models and recruitment characteristics did not influence these findings.    Conclusion  In a porcine ARDS model EELV measurement depicts PEEP-induced lung recruitment and is strongly associated with normalization of the V A /Q distribution in a model-independent fashion. Determination of EELV could be an intriguing addition in the context of lung protection strategies.

Endexpiratory lung volume measurement correlates with the ventilation/perfusion mismatch in lung injured pigs