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Background  According to the Global Initiative of Asthma, the aim of asthma treatment is to gain and maintain control. In the INTERNATIONA L  CROSS-SECT I ON A L AND LONG I TUDINAL ASSESSMENT ON A S THMA C ON TROL (LIAISON) study, we evaluated the level of asthma control and quality of life (QoL), as well as their determinants and impact in a population consulting specialist settings.    Methods  LIAISON is a prospective, multicentre, observational study with a cross-sectional and a 12-month longitudinal phase. Adults with an asthma diagnosis since at least 6 months, receiving the same asthma treatment in the 4 weeks before enrolment were included. Asthma control was assessed with the 6-item Asthma Control Questionnaire (ACQ) and QoL with the MiniAsthma Quality of Life Questionnaire (MiniAQLQ).    Results  Overall, 8111 asthmatic patients were enrolled in 12 European countries. Asthma control was suboptimal in 56.5 % of patients and it was associated with poorer asthma-related QoL, higher risk of exacerbations and greater consumption of healthcare resources.  Variables associated with suboptimal control were age, gender, obesity, smoking and comorbidities. Major determinants of poor asthma control were seasonal worsening and persisting exposure to allergens/irritants/triggers, followed by treatment-related issues.    Conclusions  The cross-sectional phase results confirm that suboptimal control is frequent and has a high individual and economic impact.    Trial registration  The clinicaltrials.gov identifier is  NCT01567280 .    Electronic supplementary material  The online version of this article (doi:10.1186/s12931-016-0374-z) contains supplementary material, which is available to authorized users.

respiratory research

Determinants and impact of suboptimal asthma control in Europe: The INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study