English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  Gastric cancer exhibits familial clustering, and gastric cancer familial relatives (GCF) tend to present with corpus-predominant gastritis and precancerous lesions as SPEM or IM after  H. pylori  infection. The study determined whether the children of gastric cancer patients (GCA) had genomic single nucleotide polymorphisms (SNPs) predisposed to the gastric precancerous lesions as spasmolytic polypeptide-expressing metaplasia (SPEM) or intestinal metaplasia (IM).    Results  There were 389 family relatives of 193 non-cardiac GCA and 173 duodenal ulcer patients (DU), received blood sampling for DNA collection. The differences of the risk alleles of SNPs in the  ITGA5 ,  ITGB1 ,  IL-10 ,  COX-2 ,  RUNX3 , and  TFF2  genes were compared between 195 children of GCA and 143 DU. The children of GCA had higher allele frequencies of  ITGA5 -1160 T-carrier ( P  = 0.006, OR[95% CI] = 2.2[1.2-4]),  ITGB1 -1949 A-carrier ( P  = 0.047; OR[95% CI] = 2.8[1.4-5.3]),  ITGB1  + 31804 C-carrier ( P  = 0.013; OR[95% CI] = 4.7[1.7-13.0]),  IL-10 -592 AA ( P  = 0.014; OR[95% CI] = 2.3[1.4-4.0]) and  COX-2- 1195 G-carrier ( P  = 0.019; OR[95% CI] = 1.7[0.9-3.2]) than DU. The combined genotype with  ITGA5 -1160/ ITGB1 -1949/ ITGB1  + 31804 as T/A/C carriers and  COX- 2-1195/ IL-10 -592 as G-carrier/AA was more prevalent in the children of GCA than in DU ( P  < 1×10 −4 ), and predisposed with a 5.3-fold risk of getting SPEM in the  H. pylori -infected children of GCA ( P  = 0.016). Such risk of getting SPEM increased to 112 folds, if combined with  RUNX3  + 492/ TFF2 -308 as A-carrier/CC in this limited study scale ( P  = 1×10 −4 ).    Conclusions  The SNPs of  ITGA5 -1160/ ITGB1 -1949/  ITGB1  + 31804 as T/A/C carriers and  COX- 2-1195/ IL-10 -592 as G-carrier/AA, or more specific to combine  RUNX3  + 492/ TFF2 -308 as A-carrier/CC shall be host factor predisposing to gastric cancer during  H. pylori  infection, and serve as marker to identify high-risk subjects for  H. pylori  eradication.    Electronic supplementary material  The online version of this article (doi:10.1186/s12929-015-0121-7) contains supplementary material, which is available to authorized users.

journal of biomedical science

Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection