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Background  It has been reported that dietary fats and genetic factors in individuals are associated with the pattern of fat distribution. This study aimed to evaluate the interaction between dietary fats intake and  Caveolin1 (CAV-1) rs 3807s992  polymorphism with fat distribution in overweight and obese women.    Methods  A total of 221 participants were included in the current cross-sectional study. Body composition, biochemical parameters were evaluated by body composition analyzer and Pars Azmoon kits and genotypes determination was performed by PCR–RFLP, dietary fats were measured using a validated semi-quantitative food frequency questionnaire (FAQ).    Results  The frequency of GG, AA and AG genotypes were 53.1, 24.6, and 22.3%, respectively, and the mean intake of total dietary fat intake was 97.47 ± 36.87 g. There was positive significant interaction between total fat intake and AA genotype on visceral fat level ( p  = 0.001), trunk fat ( p  = 0.01) and waist circumference ( p  = 0.05), positive significant interaction between total fat intake and AG genotype on the waist to hip ratio (WHR) ( p  = 0.02) and visceral fat level ( p  = 0.05), positive borderline significant interaction between saturated fatty acid and AA genotype on the trunk fat ( p  = 0.06), and between trans-fatty acids and AG genotype on WHR ( p  = 0.04), visceral fat level ( p  = 0.01), and between monounsaturated fatty acid and AG genotype on WHR ( p  = 0.04), and a borderline interaction between polyunsaturated fatty acid and AA genotypes on visceral fat level ( p  = 0.06), negative significant interaction between AG genotypes and linolenic acid on WHR ( p  = 0.04), borderline significant interaction between ALA and AG genotype on WHR ( p  = 0.06).    Conclusions  Our findings showed that  CAV-1 rs 3807992  polymorphism and dietary fats were associated with fat distributions in individuals.    Supplementary Information  The online version contains supplementary material available at 10.1186/s12920-021-01114-7.

bmc medical genomics

The interactions between dietary fats intake and Caveolin 1 rs 3807992 polymorphism with fat distribution in overweight and obese women: a cross-sectional study