English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Coronary heart disease (CHD) is the leading cause of human death worldwide. Genetic factors play an important role in the occurrence of CHD. Our study is designed to investigate the influence of  CYP7B1  polymorphisms on CHD risk.    Methods  In this case–control study, 508 CHD patients and 510 healthy individuals were recruited to determine the correlation between  CYP7B1  polymorphisms (rs7836768, rs6472155, and rs2980003) and CHD risk. The associations were evaluated by computing odds ratios (OR) and 95% confidence intervals (CI) with logistic regression analysis. The association between SNP-SNP interaction and CHD susceptibility was carried out by multifactor dimensionality reduction analyses.    Results  Our study found that rs6472155 is significantly associated with an increased risk of CHD in age > 60 years (OR 2.20, 95% CI = 1.07–4.49,  p  = 0.031), women (OR 3.17, 95% CI = 1.19–8.44,  p  = 0.021), and non-smokers (3.43, 95% CI = 1.16–10.09,  p  = 0.025). Rs2980003 polymorphism has a lower risk of CHD in drinkers (OR 0.47, 95% CI = 0.24–0.91,  p  = 0.025). Further analyses based on false-positive report probability validated these significant results. Besides, it was found that rs6472155 polymorphism was associated with uric acid level ( p  = 0.034).    Conclusion  Our study indicated that  CYP7B1  polymorphisms are related to the risk of CHD, which provides a new perspective for prevent of CHD.    Supplementary Information  The online version contains supplementary material available at 10.1186/s12920-021-01067-x.

The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population