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Background  Genetic factors play an important role in susceptibility to methamphetamine dependency. In this line, protein that interact with C-kinase-1 (PICK1) and brain-derived neurotrophic factor ( BDNF ) genes are linked to methamphetamine dependence (substance use disorder). Thus, in a case–control study, we investigated the association between polymorphisms of  PICK1  and  BDNF  genes and methamphetamine dependence in an Iranian population.    Methods  Total of 235 cases and 204 controls were recruited in a period between 2015 to 2018. The  PICK1-rs713729 ,  -rs2076369  and  BDNF-rs6265  genotypes were determined via ARMS-PCR assay. Statistical analysis was performed, using SPSS 20.0, PHASE 2.1.1 program as well as SNP Analyzer 2.0.    Results  In the present study, two polymorphisms including  PICK1-rs713729  (OR 1.38 (CI 1.08–1.52;  P - value  0.004) in multiplicative and dominant models, and  PICK1-rs2076369  (OR 1.31 (CI 1.10–1.56;  P - value  0.002) in multiplicative, dominant and co-dominant models were associated with the risk of methamphetamine abuse. Moreover, haplotype analysis showed a significant association of haplotype AG (OR 2.50 (CI 1.50–4.16;  P - value  0.0002) in dominant, recessive and co-dominant models, and haplotype TT (OR 0.67 (CI 0.50–0.91;  P - value  0.009) in dominant and co-dominant models with the risk of methamphetamine abuse. None of the polymorphisms in this study had a high level of linkage disequilibrium.    Conclusion  Our findings indicate that the  PICK1  gene polymorphism might affect the risk of methamphetamine dependency in our population.

Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case–control study