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Background  NEK2 has an established involvement in hepatocellular carcinoma (HCC) but the roles of NEK2 and its interacting proteins in HCC have not been systematically explored.    Methods  This study examined NEK2 and its interacting proteins in HCC based on multiple databases.    Results   NEK2  mRNA was highly expressed in HCC tissues compared with normal liver tissues. The survival of HCC patients with high  NEK2  mRNA expression was shorter than those with low expression. MAD1L1, CEP250, MAPK1, NDC80, PPP1CA, PPP1R2 and NEK11 were the interacting proteins of NEK2. Among them, NDC80 and CEP250 were the key interacting proteins of NEK2. Mitotic prometaphase may be the key pathway that NEK2 and its interacting proteins contributed to HCC pathogenesis.  NEK2 ,  NDC80  and  CEP250  mRNAs were highly expressed in HCC tissues compared with normal liver tissues. The mRNA levels of  NEK2  were positively correlated with those of  NDC80  or  CEP250 . Univariate regression showed that  NEK2 ,  NDC80  and  CEP250  mRNA expressions were significantly associated with HCC patients’ survival. Multivariate regression showed that  NDC80  mRNA expression was an independent predictor for HCC patients’ survival. Methylations and genetic alterations of  NEK2 ,  NDC80  and  CEP250  were observed in HCC samples. The alterations of  NEK2 ,  NDC80  and  CEP250  genes were co-occurrence. Patients with high mRNA expression and genetic alterations of  NEK2 ,  NDC80  and  CEP250  had poor prognosis.    Conclusions  NEK2 and its interacting proteins NDC80 and CEP250 play important roles in HCC development and progression and thus may be potentially used as biomarkers and therapeutic targets of HCC.

Involvement of NEK2 and its interaction with NDC80 and CEP250 in hepatocellular carcinoma