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Background  Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Recent evidence suggests that genetic factors are related to the pathogenesis of IgAN. We conducted a genome-wide association study (GWAS) to identify novel genetic susceptibility loci for IgAN in a Korean population.    Methods  We enrolled 188 biopsy-confirmed IgAN cases and 455 healthy controls for the discovery stage and explored associations between IgAN and single nucleotide polymorphisms (SNPs) using a customized DNA chip. The significant SNPs from the discovery samples were then selected for replication in an independent cohort with 310 biopsy-confirmed IgAN cases and 438 healthy controls.    Results  In the first stage, two SNPs (rs10172700 in  LOC105373592  and rs2296136 in  ANKRD16 ) were selected for further association analysis in the next stage. In the replication cohort, rs2296136 in  ANKRD16  was significantly associated with IgAN (odds ratio [OR] = 1.40, 95% confidence interval [CI] 0.99–1.98,  p  = 0.05 in log-additive model, OR = 1.55, 95% CI = 1.06–−2.27,  p  = 0.02 in dominant model, and OR = 0.70, 95% CI = 0.17–−2.84,  p  = 0.62 in recessive model). rs2296136 in  ANKRD16  also showed a significant association with IgAN in the entire study population combining GWAS and replication study ( p  = 0.0045 in log-additive model,  p  = 0.0027 in dominant model, and  p  = 0.76 in recessive model).    Conclusions  The SNPs identified in the present study could be good candidate markers for predicting IgAN in Koreans, although further experimental validation is needed.

Genome-wide association study identifies new susceptible loci of IgA nephropathy in Koreans