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Background  Interferon regulatory factor 2 (IRF2) is an important transcription factor, which can regulate the IFN response and plays a role in antiviral innate immunity in teleost.    Results  In the present study, the full-length cDNA sequence of IRF2 ( Cc IRF2) was characterized in common carp ( Cyprinus carpio  L.), which encoded a protein containing a conserved DNA-binding domain (DBD) and an IRF-associated domain (IAD). Phylogenetic analysis showed that  Cc IRF2 was most closely related with IRF2 of  Ctenopharyngodon idella .  Cc IRF2 transcripts were detectable in all examined tissues, with higher expression in the gills, spleen and brain.  Cc IRF2 expression was upregulated in immune-related tissues of common carp upon polyinosinic:polycytidylic acid (poly (I:C)) and  Aeromonas hydrophila  stimulation and induced by poly (I:C), lipopolysaccharide (LPS), peptidoglycan (PGN) and flagellin in the peripheral blood leucocytes (PBLs) and head kidney leukocytes (HKLs). In addition, overexpression of  Cc IRF2 decreased the expression of IFN and IFN-stimulated genes (ISGs), and a dual-luciferase reporter assay revealed that  Cc IRF2 could increase the activation of NF-κB.    Conclusions  These results indicate that  Cc IRF2 participates in antiviral and antibacterial immune response and negatively regulates the IFN response, which provide a new insight into the regulation of IFN system in common carp, and are helpful for the prevention and control of infectious diseases in carp farming.

bmc veterinary research

Molecular characterization and immune functional analysis of IRF2 in common carp (Cyprinus carpio L.): different regulatory role in the IFN and NF-κB signalling pathway