English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  The discovery of the superbug  mcr-1 -positive  Escherichia coli  (MCRPEC) has drew greet attention. Swine-origin multi-drug resistant MCRPEC has been a potential threat to public health and safety. However, there were few detailed studies have been reported on swine MCRPEC in Guangxi, South China.    Results  In this study, thirty-three MCRPEC strains were detected from 142  E. coli  strains from 116 samples in Guangxi in 2018. Which could be classified into eight unique STs and a total of six incompatibility plasmid groups (IncFI, IncHI1, IncY, IncN, IncI1 and IncX1). After that, the susceptibility of MCRPEC isolates to 27 antimicrobial agents belonging to 17 antimicrobial categories was tested. There were nineteen  E. coli  resistant to 3rd and 4th generation cephalosporins and twelve  E. coli  resistant to carbapenem resistan. Importantly, the MCRPEC showed high resistance highly resistance for imipenem and meropenem, which were forbidden to use in livestock production. Three MCRPEC strains were further proved to be extensively drug-resistant (XDR), and the other isolates were multi-drug-resistant (MDR). Furthermore, we found that the plasmid-carrying resistance genes coexisted with the  mcr-1  gene of the MCRPEC isolates. Which were listed as follows: β-lactamase antimicrobial resistance genes e.g. ESBL genes ( bla   CTX-M14  ,  bla   CTX-M24  ,  bla   CTX-M123  ,  bla   OXA-1  ), plasmid-mediated AmpC (pAmpC) gene ( bla   CMY-2  ), the carbapenem resistance gene ( bla   NDM-5  ), and non-β-lactamase antimicrobial resistance genes ( qnrA ,  qnrB ,  qnrS ,  aac (6′)-Ib-cr ,  tetA ,  tetB ,  sul1 ,  sul2 ,  floR ,  aadA ).    Conclusion  Thirty-three  mcr-1 -positive  E. coli  isolates in Guangxi displayed a wide profile of antimicrobial resistance. Plasmid-carrying resistance genes might be the main cause of MCRPEC multidrug resistance. This study highlighted the necessity for long-term surveillance of  mcr-1 -positive  E. coli  in pigs.    Supplementary Information  The online version contains supplementary material available at 10.1186/s12917-021-02758-4.

Extensive antimicrobial resistance and plasmid-carrying resistance genes in mcr-1-positive E. coli sampled in swine, in Guangxi, South China