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Background   Mycoplasma  ( M. )  hyopneumoniae ,  M. hyorhinis  and  M. hyosynoviae  are significant pathogens for the porcine industry worldwide. The aim of the present study was to determine the antimicrobial susceptibility of six key antimicrobials (tylosin, tilmicosin, tylvalosin, lincomycin, tiamulin and valnemulin) routinely used for treating infections caused by these pathogens. Twenty-seven  M. hyopneumoniae , 48  M. hyorhinis  and 40  M. hyosynoviae  field strains isolated from clinical samples from different Southern European countries between 2013 and 2018 using broth microdilution method were evaluated.    Results  Tylvalosin exhibited the highest in vitro activity among the macrolides assayed, with MIC 90  values 4 to 5 two-fold dilutions lower than those of tylosin and tilmicosin. The pleuromutilin valnemulin showed one of the highest in vitro activities against the three mycoplasma species. On the contrary, lincomycin exhibited the highest MIC values of the antimicrobials tested.    Conclusions  The data obtained in the present study supports the use of pleuromutilins and macrolides for the control of infections caused by porcine mycoplasmas. The use of lincomycin for the treatment of porcine mycoplasma infections should be carefully evaluated due to the presence of circulating field isolates with decreased susceptibility to this antimicrobial.

Antimicrobial susceptibility profiles of porcine mycoplasmas isolated from samples collected in southern Europe